1-Pyrrolidineethanamine → HCID 69277941, compound

HRID 2251146Notes

Reaction equation

[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([OH:17])=O)[CH:11]=2)[C:6]1=[O:18].[N:23]1([CH2:28][CH2:29][NH2:30])[CH2:27][CH2:26][CH2:25][CH2:24]1>>[Cl-:1].[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([NH:30][CH2:29][CH2:28][NH+:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)=[O:17])[CH:11]=2)[C:6]1=[O:18]

Participants

Reactant 2

HCID 13441-Pyrrolidineethanamine

HCID 2994323HCID 2994323, compound

Product 1

HCID 69277941HCID 69277941, compound

Procedure

2-(2-chloro-benzyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-carboxylic acid (100 mg, 0.316 mmol) and 2-pyrrolidin-1-yl-ethylamine (100 μL, 0.792 mmol) were reacted with each other. Target compound in the amount of 121 mg (85%) was obtained by following the procedure described in Example 1.

Workup

customTarget compound in the amount of 121 mg (85%) was obtained

Sources & evidence

ORD record: ord-8e014f3075434a06824bcfaba7a70eb2
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319098B2

Reaction notes

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