1-(3-Aminopropyl)-2-pipecoline → HCID 69278584, compound

HRID 2251150Notes

Reaction equation

HRID 2251150 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:16]([OH:18])=O)[CH:12]=2)[C:7]1=[O:19].[CH3:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][N:25]1[CH2:30][CH2:31][CH2:32][NH2:33]>>[Cl-:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:16]([NH:33][CH2:32][CH2:31][CH2:30][NH+:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH:24]3[CH3:23])=[O:18])[CH:12]=2)[C:7]1=[O:19]

Participants

3

Reactant 2

HCID 5202111-(3-Aminopropyl)-2-pipecolineHCID 69277800HCID 69277800, compound

Product 1

HCID 69278584HCID 69278584, compound

Procedure

2-(3-chloro-benzyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-carboxylic acid (100 mg, 0.316 mmol) and 3-(2-methylpiperidin-1-yl)propan-1-amine (138 μL, 0.792 mmol) were reacted with each other. Target compound in the amount of 106 mg (68%) was obtained by following the procedure described in Example 1.

Workup

  1. customTarget compound in the amount of 106 mg (68%) was obtained

Sources & evidence

ORD record
ord-35bb00cea67a4d7082915258732e93ff
Source dataset
uspto-grants-2008_01
Patent number
US07319098B2

Reaction notes

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