1-Pyrrolidineethanamine → HCID 69277600, compound

HRID 2251156Notes

Reaction equation

[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:17](O)=[O:18])[CH:13]=3)[C:8]2=[O:20])=[CH:4][CH:3]=1.[N:23]1([CH2:28][CH2:29][NH2:30])[CH2:27][CH2:26][CH2:25][CH2:24]1>>[Cl-:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:17]([NH:30][CH2:29][CH2:28][NH+:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)=[O:18])[CH:13]=3)[C:8]2=[O:20])=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 13441-Pyrrolidineethanamine

HCID 9079397HCID 9079397, compound

Product 1

HCID 69277600HCID 69277600, compound

Procedure

2-(4-chloro-benzyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-carboxylic acid (100 mg, 0.316 mmol) and 2-pyrrolidin-1-yl-ethylamine (100 μL, 0.792 mmol) were reacted with each other. Target compound in the amount of 106 mg (75%) was obtained by following the procedure described in Example 1.

Workup

customTarget compound in the amount of 106 mg (75%) was obtained

Sources & evidence

ORD record: ord-f597ecb841a7411e8bc388a68f85f34e
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319098B2

Reaction notes

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