HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → [4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Reactant | 1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine | HCID 46837495 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Formic acid methanol | HCID 18963719 | — |
| Product | [4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone | HCID 11352274 | — |
Reaction Steps
A mixture of 0.05 mmol 2-isopropoxy-5-methanesulfonyl-benzoic acid (Compound 1.2), 0.06 mmol 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine, 0.055 mmol TBTU and 0.25 mmol DIPEA in 1 ml DMF was stirred at RT for 16 h. 0.5 ml MeOH/HCOOH 1/1 was added and the mixture was subjected to reversed phase preparative HPLC separation eluting with an acetonitrile/water gradient yielding the title compound. MS (m/e): 489.2 (MH+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319099B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-3ab9d1517f334654a91d938d6550f0df |
| Source note | uspto-grants-2008_01 |