HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Methanesulfonyl-2-(2,2,3,3,3-pentafluoro-propoxy)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,2,3,3,3-Pentafluoropropyl trifluoromethanesulfonate | HCID 2776019 | — |
| Reactant | 2-Hydroxy-5-methylsulfonylbenzoic acid methyl ester | HCID 23503163 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 5-Methanesulfonyl-2-(2,2,3,3,3-pentafluoro-propoxy)-benzoic acid methyl ester | HCID 86600706 | 55.9% |
Reaction Steps
A solution of methyl 5-(methanesulfonyl)salicylate [101371-44-2] (0.50 g), trifluoro-methanesulfonic acid 2,2,3,3,3-pentafluoro-propyl ester (0.67 g) and potassium carbonate (0.60 g) in acetone was stirred at 60° C. for 5 hours. The reaction mixture was then concentrated in vacuo and purified by column chromatography (SiO2) to yield the title compound as a white solid (0.44 g). MS (m/e): 363.1 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319099B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-15558b9011854f77a1d57ca88b9324fc |
| Source note | uspto-grants-2008_01 |