2-(4-Benzylpiperazin-1-yl)-5-trifluoromethylpyrimidine → 2-(Piperazin-1-YL)-5-(trifluoromethyl)pyrimidine

HRID 2251186Notes

Reaction equation

HRID 2251186 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO>[N:11]1([C:14]2[N:15]=[CH:16][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:18][N:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

3

Reactant 1

HCID 468388822-(4-Benzylpiperazin-1-yl)-5-trifluoromethylpyrimidine

Product 1

HCID 163147972-(Piperazin-1-YL)-5-(trifluoromethyl)pyrimidineYield 90.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 2-(4-Benzyl-piperazin-1-yl)-5-trifluoromethyl-pyrimidine (0.63 g) in methanol was added Palladium-C (Degussa E101N; 5%), and the reaction mixture was heated at 60° C. under hydrogen atmosphere. The reaction mixture was then allowed to cool down to room temperature, the catalyst was filtered off, and solvent was removed in vacuo to yield the title compound as a colorless solid (0.41 g). MS (m/e): 233.1 (M+H+).

Workup

  1. temperatureto cool down to room temperature
  2. filtrationthe catalyst was filtered off
  3. customsolvent was removed in vacuo

Sources & evidence

ORD record
ord-4372277aadd24f10a7466e007c5bc7b7
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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