tert-Butyl piperazine-1-carboxylate → 4-[4-(2-Methyl-2H-tetrazol-5-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 2251202Notes

Reaction equation

HRID 2251202 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[N:10][N:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.[C:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]>>[C:17]([O:16][C:14]([N:21]1[CH2:26][CH2:25][N:24]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[N:9]=[N:10][N:11]([CH3:13])[N:12]=3)=[CH:4][CH:3]=2)[CH2:23][CH2:22]1)=[O:15])([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 6109772-Methyl-5-(4-bromophenyl)tetrazole

Product 1

HCID 690384864-[4-(2-Methyl-2H-tetrazol-5-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Procedure

Prepared in analogy to example 4.4 (a) from 5-(4-Bromo-phenyl)-2-methyl-2H-tetrazole and N-BOC-piperazine. MS (m/e): 345.1 (MH+, 41%)

Sources & evidence

ORD record
ord-d3ba3bae32774240a731d6f7812d3a02
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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