HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dichloropyrazine → Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dichloropyrazine | HCID 78504 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate | HCID 18186946 | — |
Reaction Steps
A mixture of 10 mmol 2,6-dichloropyrazine and 21 mmol of N-BOC-piperazine in 15 ml acetonitrile was heated under reflux for 1.5 hours. The reaction mixture was concentrated and purified by chromatography (SiO2; dichloromethane/methanol 95:5) to yield the title compound as a colorless solid. MS (m/e): 299.2 (MH+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319099B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-57315e5e3a184bd8bab95fefca69b400 |
| Source note | uspto-grants-2008_01 |