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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251226Generated: November 3, 2026

4-(Piperazin-1-yl)benzonitrile → 4-[4-(2,6-Difluoro-3-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

https://huagongshe.com/reaction/2251226

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Piperazin-1-yl)benzonitrileHCID 2733995—
Reactant2,6-Difluoro-3-(methylsulfonyl)benzoic acidHCID 43140935—
Product4-[4-(2,6-Difluoro-3-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrileHCID 69036287—

Reaction Steps

Prepared in analogy to example 5 from 4-piperazin-1-yl-benzonitrile and 2,6-difluoro-3-methanesulfonyl-benzoic acid. MS (m/e): 406.3 (MH+, 84%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07319099B2
Source datasetuspto-grants-2008_01
ORD IDord-0660c56eb7a74568aba886973cfe57b2
Source noteuspto-grants-2008_01