HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 1,3-Dioxol-2-one, 4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-, dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Butyrophenone, 4'-fluoro-2-hydroxy-4-(4-(o-methoxyphenyl)-1-piperazinyl)- | HCID 39883 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1,3-Dioxol-2-one, 4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-, dihydrochloride | HCID 56880 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of 20 g of 1-p-fluorobenzoyl-1-hydroxy-3-(4-(2-methoxyphenyl)-1-piperazinyl)propane in 200 cc of anhydrous chloroform is added in 60 minutes to 33 ml of a 20% phosgene solution in toluene, stirred and cooled to 0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04235904 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-9c5fc7f934b54651a11513c9fb1e1e43 |
| Source note | uspto-grants-1980_11 |