HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251233Generated: November 2, 2026
Potassium Carbonate → 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid methyl ester
https://huagongshe.com/reaction/2251233
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxy-5-methylsulfonylbenzoic acid methyl ester | HCID 23503163 | — |
| Reactant | 1, 1, 1-Trifluoropropan-2-yl trifluoromethanesulfonatc | HCID 57445280 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid methyl ester | HCID 58863350 | — |
Reaction Steps
A mixture of 21.7 mmol 2-Hydroxy-5-methanesulfonyl-benzoic acid methyl ester [68029-77-6], 32.5 mmol trifluoro-methanesulfonic acid 2,2,2-trifluoro-1-methyl-ethyl ester [212556-43-9], 43.4 mmol potassium carbonate in 87 ml DMF was stirred at 80° C. for 48 hours. After cooling to RT, the mixture was concentrated in vacuo, taken in water and stirred for 1 hour. Filtration yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07319099B2 |
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| Source dataset | uspto-grants-2008_01 |
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| ORD ID | ord-1311ebb01e614676a8f65c20dec5d26b |
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| Source note | uspto-grants-2008_01 |
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