4-Nitro-2-(trifluoromethyl)pyridine 1-oxide → 1-(2-(Trifluoromethyl)Pyridin-4-Yl)Piperazine

HRID 2251235Notes

Reaction equation

HRID 2251235 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][N+:7]([O-])=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:5]=1)([O-])=O.BrC1[CH:21]=[C:20](C(F)(F)F)[N:19]=[C:18](C)[CH:17]=1>>[F:12][C:11]([F:14])([F:13])[C:6]1[CH:5]=[C:4]([N:1]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH:9]=[CH:8][N:7]=1

Participants

3

Reactant 2

HCID 103529914-Nitro-2-(trifluoromethyl)pyridine 1-oxideHCID 573515384-Bromo-2-methyl-6-(trifluoromethyl)pyridine

Product 1

HCID 690375471-(2-(Trifluoromethyl)Pyridin-4-Yl)Piperazine

Procedure

The compound can be prepared from 4-Nitro-2-trifluoromethyl-pyridine 1-oxide [147149-97-1] in analogy to the procedure used for the preparation of 4-Bromo-2-methyl-6-trifluoromethyl-pyridine [615579-78-1] (WO03087056). MS (m/e): 227 (M+H+, 100%)

Sources & evidence

ORD record
ord-43b8cfe617d4476bab8e24aad21ebadc
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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