Ethanol → HCID 12884010, compound

HRID 225125Notes

Reaction equation

HRID 225125 reaction equation
C([N:9]1[CH2:21][C:20]2[C:19](=[O:22])[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]([CH3:23])[C:11]=2[CH2:10]1)(=O)C1C=CC=CC=1.[OH-].[K+].C(O)C>CCOCC.O>[CH3:23][N:12]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=2[C:19](=[O:22])[C:20]2[CH2:21][NH:9][CH2:10][C:11]1=2

Participants

6

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 12884007HCID 12884007, compound

Product 1

HCID 12884010HCID 12884010, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 10 g of 2-benzoyl-1,2,3,4-tetrahydro-4-methyl-9H-pyrrolo[3,4-b]quinolin-9-one, 10 g of potassium hydroxide, 10 ml of water and 100 ml of ethanol is heated at reflux for 17 hours, cooled, diluted with 50 ml each of ether and water and filtered. The recrystallisation of the residue from methanol and ether yields 1,2,3,4-tetrahydro-4-methyl-9H-pyrrolo[3,4-b]quinolin-9-one. M.P. 209°-213° (decomposition).

Workup

  1. temperatureis heated
  2. temperatureat reflux for 17 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. customThe recrystallisation of the residue from methanol and ether

Sources & evidence

ORD record
ord-6ec7f3af57c34775b79f0823025e6fee
Source dataset
uspto-grants-1980_11
Patent number
US04235907

Reaction notes

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