HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 69038716, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(4-(Trifluoromethyl)phenyl)piperazine | HCID 121718 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Cyano-2-isopropoxybenzoic acid | HCID 21100297 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69038716 | HCID 69038716 | — |
Reaction Steps
To a solution of 3.6 mmol 5-cyano-2-isopropoxy-benzoic acid (compound 1.13) in 20 ml THF were added 4.0 mmol TBTU, 21.6 mmol N-ethyldiisopropylamine and 4.0 mmol 1-(4-trifluoromethyl-phenyl)-piperazine (commercial). The reaction was then stirred at RT for 16 h, concentrated in vacuo, and purified by chromatography on silica gel (eluant: ethyl acetate/heptane 1:1) to afford the title compound. MS (m/e): 418.3 (M+H+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319099B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-a935d61aad2a4f3e9f09e1ef8b11eba8 |
| Source note | uspto-grants-2008_01 |