Triphenylphosphine → HCID 24757446, compound

Participants

Reaction Steps

A mixture of 4-amino-3-chlorophenol (1.14 g, 7.9 mmol), triphenylphosphine (2.08 g, 7.9 mmol), [3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methanol (2.27 g, 7.9 mmol) in dichloromethane (20 mL) was treated with diisopropylazidodicarboxylate (1.57 mL, 7.9 mmol) dropwise. After stirring at ambient temperature for 16 h, the material was chromatographed on silica gel eluting with dichloromethane. Yield=1.73 g (53%) of 2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}aniline.

Provenance & Evidence