Water → HCID 58755337, compound

Participants

Reaction Steps

A solution of methyl 3-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)amino]sulfonyl}benzoate (32 mg, 56 μmol) in dimethylformamide (560 μL) was stirred with cesium carbonate (91 mg, 280 μmol) and methyl iodide (17.3 μL, 280 μmol) at 80° C. in a sealed vial. Water (2 mL) was added and the product was extracted with 50% ethyl acetate/hexanes. Yield=31 mg 94%) of methyl 3-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)(methyl)amino]sulfonyl}benzoate.

Provenance & Evidence