Sodium Iodide → HCID 58755318, compound

Participants

Reaction Steps

A mixture of 4-{[3-chloro-4-(chloromethyl)phenoxy]methyl}-3-(2,6-dichlorophenyl)-5-isopropylisoxazole (50 mg, 112 μmol), potassium carbonate (16.9 mg, 122 μmol), sodium iodide (18.3 mg, 110 μmol), and methyl 4-hydroxybenzoate (16.7 mg, 110 μmol) in dimethylformamide (0.6 mL) was stirred at ambient temperature overnight. The mixture was filtered, condensed to a residue, and was chromatographed on silica gel eluting with 33% ethyl acetate/hexanes. Yield=41 mg (65%) of methyl 4-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzyl)oxy]-benzoate.

Provenance & Evidence