Sodium Iodide → HCID 69207685, compound

Participants

Reaction Steps

A mixture of 4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-isopropylisoxazole (104 mg, 340 μmol), 2-methyl-4hydroxyacetophenone (50 mg, 330 μmol), potassium carbonate (45 mg, 320 μmol), sodium iodide (9.9 mg, 66 μmol) in acetone (2.2 mL) was refluxed for 5 h. The reaction was filtered over a plug of silica gel, rinsed with ethyl acetate and condensed to a residue. Yield=138 mg (100%) of 1-(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)ethanone.

Provenance & Evidence