Potassium Iodide → HCID 23329041, compound

Participants

Reaction Steps

A mixture of 10 g of γ-chloro-2-hydroxy-4-fluorobutyrophenone, 6.6 g of 4-(2-keto-1-benzimidazolinyl)piperidine, 2.6 g of sodium hydrogen carbonate, 0.05 g of potassium iodide and 300 ml of toluene was refluxed for 27 hours. The resulting mixture was poured into ice water and extracted with chloroform. The extract was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residual viscous oil was chromatographed over silica gel (100-200 mesh) with ethyl acetate as an eluting agent to give γ-[4-(2-keto-1-benzimidazolinyl)piperidin-1-yl]-2-hydroxy-4-fluorobutyrophenone, M.P. 175°-181° C.

Provenance & Evidence