Potassium Iodide → HCID 23329047, compound

Participants

Reaction Steps

A mixture of 18.75 g of γ-chloro-2-hydroxy-4-fluorobutyrophenone, 5.25 g of sodium hydrogen carbonate, 15 g of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one, 0.02 g of potassium iodide and 2 liters of toluene was refluxed for 80 hours. The resulting mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residual solid was washed with diethyl ether to give γ-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]decan-8-yl)-2-hydroxy-4-fluorobutyrophenone, M.P. 215°-220° C.

Provenance & Evidence