HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-chloro-N-(2-methoxyphenyl)-3-nitrobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Methoxyaniline | HCID 7000 | — |
| Reactant | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-chloro-N-(2-methoxyphenyl)-3-nitrobenzenesulfonamide | HCID 2887683 | — |
Reaction Steps
4-Chloro-3-nitrobenzenesulfonamide (1.73 g, 6.78 mmol) was dissolved in CH2Cl2 (7.0 mL). o-Anisidine (1.00 g, 8.13 mmol) was added dropwise at room temperature, followed by a slow addition of pyridine (2.0 mL). After 16 h of continued stirring, the reaction mixture was diluted with EtOAc (50 mL) and washed with 1 M HCl (3×50 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319097B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-4b52d90d551e410785ac8e32f7feafa4 |
| Source note | uspto-grants-2008_01 |