HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → HCID 23329184, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ethyl 3-methyl-3-azabicyclo[3.1.0]hexane-1-carboxylate | HCID 54344564 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 23329184 | HCID 23329184 | — |
Reaction Steps
A solution of 10 g of 3-methyl-3-azabicyclo[3.1.0]-hexane-1-carboxylic acid ethyl ester in 20 ml of ethanol is treated with a solution of 18.8 g of Ba(OH)2 ·8H2O in 500 ml of water. The resultant mixture is boiled under reflux for 15 hours. After cooling, the mixture is neutralized with 10% sulphuric acid. The resultant barium sulphate is filtered off. The filtrate is evaporated and taken up in methanol. After filtration through talc, the filtrate is concentrated to yield the title compound as crystals of M.Pt. 193°-195°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04235921 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-c5ad1d9922ab4bc69d8c6c9a7983966e |
| Source note | uspto-grants-1980_11 |