HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 69099470, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,5-Dibromopyrimidine | HCID 10955588 | — |
| Reactant | HCID 59643115 | HCID 59643115 | — |
| Product | HCID 69099470 | HCID 69099470 | 37% |
Reaction Steps
Condensation of ethyl 2-methyl-2-[4-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]propanoate (5.16 g; 12.6 mmol) with 2,5-dibromo-pyrimidine (3.0 g; 10.5 mmol) as per general procedure E (conditions: 1.1 eq DIEA, 210C, 2 hr) provided after chromatography the intermediate ethyl 2-[4-(2-{(5-bromopyrimidin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate (2.2 g; 37% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319104B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-f73d2c1840e5400ea6bffe7205729a5f |
| Source note | uspto-grants-2008_01 |