HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 69099787, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-5-ethylpyrimidine | HCID 3572763 | — |
| Reactant | HCID 59643222 | HCID 59643222 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 69099787 | HCID 69099787 | 23% |
Reaction Steps
Condensation of ethyl 2-[2-bromo-4-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate (500 mg; 1.02 mmol) with 2-chloro-5-ethyl-pyrimidine (1 eq) as per general procedure E (conditions: 1.1 eq DIEA, toluene, 200C, 14 hr) provided the intermediate ethyl 2-[2-bromo-4-(2-{(5-ethylpyrimidin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate (134 mg; 23% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319104B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-8a669872bd11422e96b9b5f0ae2d23f5 |
| Source note | uspto-grants-2008_01 |