HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 59643341, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-5-ethylpyrimidine | HCID 3572763 | — |
| Reactant | HCID 59643315 | HCID 59643315 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59643341 | HCID 59643341 | 85.9% |
Reaction Steps
Condensation of 4-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)phenol (1.20 g; 4.06 mmol) with 2-chloro-5-ethyl-pyrimidine (0.52 ml; 4.27 mmol) as per general procedure E (conditions: 1.1 eq. DIEA, toluene, 210C, 16 hr) provided the title compound (1.40 g; 85% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319104B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-1df6b59119cd4aadb784dce78d5b6235 |
| Source note | uspto-grants-2008_01 |