HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)benzaldehyde → N-[2-(4-methoxyphenyl)-2-methylpropyl]-N-[4-(trifluoromethyl)benzyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)benzaldehyde | HCID 67996 | — |
| Reactant | 2-(4-Methoxyphenyl)-2-methylpropan-1-amine | HCID 3581364 | — |
| Product | N-[2-(4-methoxyphenyl)-2-methylpropyl]-N-[4-(trifluoromethyl)benzyl]amine | HCID 69099563 | 84.1% |
Reaction Steps
Reductive amination of 2-(4-methoxyphenyl)-2-methylpropan-1-amine (500 mg; 2.79 mmol) with 4-(trifluoromethyl)benzaldehyde (0.38 ml; 2.79 mmol) as per general procedure A afforded N-[2-(4-methoxyphenyl)-2-methylpropyl]-N-[4-(trifluoromethyl)benzyl]amine (792 mg; 84% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319104B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-c38da1a09cd2469789d17028330a47aa |
| Source note | uspto-grants-2008_01 |