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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251500Generated: October 25, 2026

1-(Bromomethyl)-4-(trifluoromethyl)benzene → 4-(2-{(5-Ethylpyrimidin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)-2-methylphenol

https://huagongshe.com/reaction/2251500

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 123062—
Reactant5-ethyl-N-[2-(4-methoxy-3-methylphenyl)ethyl]pyrimidin-2-amineHCID 59643398—
Product4-(2-{(5-Ethylpyrimidin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)-2-methylphenolHCID 59643136—

Reaction Steps

Similarly prepared from 5-ethyl-N-[2-(4-methoxy-3-methylphenyl)ethyl]pyrimidin-2-amine and 4-trifluoromethylbenzyl bromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07319104B2
Source datasetuspto-grants-2008_01
ORD IDord-85a67e4eb7944c4793bc724fefda8f8b
Source noteuspto-grants-2008_01