1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 59643122, compound

HRID 2251502Notes

Reaction equation

HRID 2251502 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([NH:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([F:20])[CH:13]=2)=[N:7][CH:8]=1)[CH3:2].[F:21][C:22]([F:32])([F:31])[C:23]1[CH:30]=[CH:29][C:26]([CH2:27]Br)=[CH:25][CH:24]=1>>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([N:9]([CH2:27][C:26]2[CH:25]=[CH:24][C:23]([C:22]([F:21])([F:31])[F:32])=[CH:30][CH:29]=2)[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([F:20])[CH:13]=2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 59643126HCID 59643126, compound

Product 1

HCID 59643122HCID 59643122, compound

Procedure

Similarly prepared from 5-ethyl-N-[2-(3-fluoro-4-methoxyphenyl)ethyl]pyrimidin-2-amine and 4-trifluoromethyl benzyl bromide.

Sources & evidence

ORD record
ord-1680223b70a04f12979228620ca1d614
Source dataset
uspto-grants-2008_01
Patent number
US07319104B2

Reaction notes

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