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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251505Generated: November 3, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 2-Bromo-4-(2-{(5-ethylpyrimidin-2-yl)[4-(trifluoromethoxy)benzyl]amino}ethyl)phenol

https://huagongshe.com/reaction/2251505

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
ReactantN-[2-(3-Bromo-4-methoxyphenyl)ethyl]-5-ethylpyrimidin-2-amineHCID 59643362—
Product2-Bromo-4-(2-{(5-ethylpyrimidin-2-yl)[4-(trifluoromethoxy)benzyl]amino}ethyl)phenolHCID 59643153—

Reaction Steps

Similarly prepared from N-[2-(3-bromo-4-methoxyphenyl)ethyl]-5-ethylpyrimidin-2-amine and 4-trifluoromethoxy benzyl bromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07319104B2
Source datasetuspto-grants-2008_01
ORD IDord-7d1736c3c8884a0c8a4c863cfc4174fb
Source noteuspto-grants-2008_01