1-(Bromomethyl)-4-ethylbenzene → 2-Bromo-4-{2-[(4-ethylbenzyl)(5-ethylpyrimidin-2-yl)amino]ethyl}phenol

HRID 2251507Notes

Reaction equation

HRID 2251507 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH:12][C:13]2[N:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][N:14]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.[CH2:21]([C:23]1[CH:30]=[CH:29][C:26]([CH2:27]Br)=[CH:25][CH:24]=1)[CH3:22]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][N:12]([CH2:27][C:26]2[CH:29]=[CH:30][C:23]([CH2:21][CH3:22])=[CH:24][CH:25]=2)[C:13]2[N:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][N:14]=2)[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

3

Reactant 2

HCID 122315601-(Bromomethyl)-4-ethylbenzeneHCID 59643362N-[2-(3-Bromo-4-methoxyphenyl)ethyl]-5-ethylpyrimidin-2-amine

Product 1

HCID 596431502-Bromo-4-{2-[(4-ethylbenzyl)(5-ethylpyrimidin-2-yl)amino]ethyl}phenol

Procedure

Similarly prepared from N-[2-(3-bromo-4-methoxyphenyl)ethyl]-5-ethylpyrimidin-2-amine and 4-ethyl benzyl bromide.

Sources & evidence

ORD record
ord-b2b25635311c40e698d2e4ab04911893
Source dataset
uspto-grants-2008_01
Patent number
US07319104B2

Reaction notes

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