1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 59643367, compound

HRID 2251508Notes

Reaction equation

HRID 2251508 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([NH:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([C:20]([F:23])([F:22])[F:21])[CH:13]=2)=[N:7][CH:8]=1)[CH3:2].[F:24][C:25]([F:36])([F:35])[O:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[CH:29][CH:28]=1>>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([N:9]([CH2:31][C:30]2[CH:33]=[CH:34][C:27]([O:26][C:25]([F:24])([F:35])[F:36])=[CH:28][CH:29]=2)[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([C:20]([F:23])([F:22])[F:21])[CH:13]=2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 59643260HCID 59643260, compound

Product 1

HCID 59643367HCID 59643367, compound

Procedure

Similarly prepared from 5-ethyl-N-{2-[4-methoxy-3-(trifluoromethyl)phenyl]ethyl}pyrimidin-2-amine and 4-trifluoromethoxy benzyl bromide.

Sources & evidence

ORD record
ord-906f315507844a7289f71d15a52ab61d
Source dataset
uspto-grants-2008_01
Patent number
US07319104B2

Reaction notes

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