1-(Bromomethyl)-3-(trifluoromethoxy)benzene → HCID 59643381, compound

HRID 2251509Notes

Reaction equation

HRID 2251509 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([NH:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([C:20]([F:23])([F:22])[F:21])[CH:13]=2)=[N:7][CH:8]=1)[CH3:2].[F:24][C:25]([F:36])([F:35])[O:26][C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH2:30]Br>>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([N:9]([CH2:30][C:29]2[CH:32]=[CH:33][CH:34]=[C:27]([O:26][C:25]([F:24])([F:35])[F:36])[CH:28]=2)[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([C:20]([F:23])([F:22])[F:21])[CH:13]=2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7371761-(Bromomethyl)-3-(trifluoromethoxy)benzeneHCID 59643260HCID 59643260, compound

Product 1

HCID 59643381HCID 59643381, compound

Procedure

Similarly prepared from 5-ethyl-N-{2-[4-methoxy-3-(trifluoromethyl)phenyl]ethyl}pyrimidin-2-amine and 3-trifluoromethoxy benzyl bromide.

Sources & evidence

ORD record
ord-9636d8b0e1e44a71a05b6c30f84db1e9
Source dataset
uspto-grants-2008_01
Patent number
US07319104B2

Reaction notes

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