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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251521Generated: October 26, 2026

Trifluoroacetic acid → [4-(2-{(5-Methylpyridin-2-yl)[3-(trifluoromethoxy)benzyl]amino}ethyl)phenoxy]acetic acid

https://huagongshe.com/reaction/2251521

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactanttert-Butyl bromoacetateHCID 79177—
Reactant4-(2-{(5-Methylpyridin-2-yl)[3-(trifluoromethoxy)benzyl]amino}ethyl)phenolHCID 59643320—
Product[4-(2-{(5-Methylpyridin-2-yl)[3-(trifluoromethoxy)benzyl]amino}ethyl)phenoxy]acetic acidHCID 59643186—

Reaction Steps

Similarly prepared by alkylation of 4-(2-{(5-methylpyridin-2-yl)[3-(trifluoromethoxy)benzyl]amino}ethyl)phenol with tert-butyl-bromo-acetate, followed by standard TFA hydrolysis (general procedure I).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07319104B2
Source datasetuspto-grants-2008_01
ORD IDord-22703ab2737b4400a738bf7375d85a61
Source noteuspto-grants-2008_01