HCID 59643169, compound → HCID 69099548, compound

HRID 2251523Notes

Reaction equation

HRID 2251523 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([CH2:18][CH2:19][CH3:20])[CH:12]=2)=[N:6][CH:7]=1.C(C1C=NC(N(CC(C)(C2C=CC(O[CH2:63][C:64]3[N:65]=[N:66][NH:67][N:68]=3)=C(CCC)C=2)C)CC2C=CC(OC(F)(F)F)=CC=2)=NC=1)C>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:63][C:64]3[N:65]=[N:66][NH:67][N:68]=3)=[C:13]([CH2:18][CH2:19][CH3:20])[CH:12]=2)[CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:31])[F:30])=[CH:26][CH:27]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 59643169HCID 59643169, compoundHCID 69099629HCID 69099629, compound

Product 1

HCID 69099548HCID 69099548, compound

Procedure

The title compound was prepared from 4-(2-{(5-methylpyridin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)-2-propylphenol via a two-step sequence similar to that described for 5-ethyl-N-{2-methyl-2-[3-propyl-4-(2H-tetraazol-5-ylmethoxy)phenyl]propyl}-N-[4-(trifluoromethoxy)benzyl]pyrimidin-2-amine.

Sources & evidence

ORD record
ord-eff2c349e8de4410b61e6cfb28943908
Source dataset
uspto-grants-2008_01
Patent number
US07319104B2

Reaction notes

Loading…