Diisopropylethylamine → HCID 59643195, compound

Participants

Reaction Steps

A mixture of ethyl 2-methyl-2-[4-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]propanoate (1.05 g; 2.57 mmol), 2-chloro-5-acetyl-pyridine (0.40 g; 2.57 mmol) and DIEA (0.36 g; 2.83 mmol) was heated in a pressure tube at 180C for 5 hr. Upon cooling, the residue was chromatographed using 20% ethyl acetate-hexane mixtures to afford ethyl 2-[4-(2-{(5-acetylpyridin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate (0.48 g; 35% yield).

Provenance & Evidence