HCID 59643238, compound → HCID 59643282, compound

Participants

Reaction Steps

A solution of ethyl 2-methyl-2-[4-(2-{(5-nitropyridin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]propanoate (149 mg; 1.73 mmol) in 10 ml of MeOH was treated with 10% Pd/C (60 mg) and hydrogenated under balloon pressure for 2 hr. The catalyst was filtered off and washed with chloroform/methanol. The filtrate was concentrated and the residue purified by radial chromatography using a methanol-dichloromethane gradient (1–10%) to afford the title compound as a dark-colored oil (125 mg; 89% yield).

Provenance & Evidence