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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251548Generated: October 26, 2026

Trifluoroacetic acid → [4-(3-{(5-Isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenoxy]acetic acid

https://huagongshe.com/reaction/2251548

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactanttert-Butyl bromoacetateHCID 79177—
Reactant4-(3-{(5-Isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenolHCID 59643199—
Product[4-(3-{(5-Isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenoxy]acetic acidHCID 59643235—

Reaction Steps

Similarly prepared by alkylation of 4-(3-{(5-isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenol with tert-butyl-bromo-acetate followed by standard TFA hydrolysis.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07319104B2
Source datasetuspto-grants-2008_01
ORD IDord-e5d825b786f54bf5be723a54f309c4c4
Source noteuspto-grants-2008_01