2-Chlorobenzothiazole → HCID 59643421, compound

HRID 2251555Notes

Reaction equation

[CH3:1][C:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)=[CH:12][CH:11]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].Cl[C:31]1[S:32][C:33]2[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=2[N:35]=1.[OH-].[Na+]>>[S:32]1[C:33]2[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=2[N:35]=[C:31]1[N:18]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:28])([F:27])[F:29])=[CH:22][CH:21]=1)[CH2:17][CH2:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:2]([CH3:1])([CH3:8])[C:3]([OH:5])=[O:4])=[CH:11][CH:12]=1

Participants

Reactant 3

HCID 119872-Chlorobenzothiazole

HCID 14798Sodium Hydroxide

HCID 59643115HCID 59643115, compound

Product 1

HCID 59643421HCID 59643421, compound

Procedure

Similarly, condensation of ethyl 2-methyl-2-[4-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]propanoate with 2-chlorobenzothiazole, followed by standard hydrolysis with NaOH afforded the title compound.

Sources & evidence

ORD record: ord-0f7826a4c3e3452cae120819bb76bd26
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319104B2

Reaction notes

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