2,6-Dichlorobenzothiazole → HCID 59643161, compound

HRID 2251557Notes

Reaction equation

[CH3:1][C:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)=[CH:12][CH:11]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].Cl[C:31]1[S:32][C:33]2[CH:39]=[C:38]([Cl:40])[CH:37]=[CH:36][C:34]=2[N:35]=1>>[Cl:40][C:38]1[CH:37]=[CH:36][C:34]2[N:35]=[C:31]([N:18]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[CH2:17][CH2:16][C:13]3[CH:12]=[CH:11][C:10]([O:9][C:2]([CH3:8])([CH3:1])[C:3]([OH:5])=[O:4])=[CH:15][CH:14]=3)[S:32][C:33]=2[CH:39]=1

Participants

Reactant 2

HCID 771762,6-Dichlorobenzothiazole

HCID 59643115HCID 59643115, compound

Product 1

HCID 59643161HCID 59643161, compound

Procedure

Similarly prepared from ethyl 2-methyl-2-[4-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]propanoate and 2,6-dichloro benzothiazole. 1H NMR (CDCl3) δ 7.55 (d, 2H, J=8.0), 7.52 (d, 1H, J=2.0), 7.47 (d, 1H, J=8.0), 7.32 (d, 2H, J=8.0), 7.24 (dd, 1H, J=8.0; 2.0), 7.07 (d, 2H, J=8.6), 6.86 (d, 2H, J=8.6), 4.67 (s, 2H), 3.65 (t, 2H, J=7.2), 2.93 (t, 2H, J=7.2), 1.53 (s, 6H). MS: m/z 549 (M+1).

Sources & evidence

ORD record: ord-264063693c9a45f0b5ab7727d362054d
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319104B2

Reaction notes

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