反应详情

To a mixture of 2-(4-bromophenyl)-2-oxoethyl cyclopropane carboxylate (6.00 g, 21.19 mmol) and acetamide (6.60 g, 111.73 mmol) was added BF3/Et2O (4 ml). The mixture was heated to 140C for 2.5 h. Upon cooling, water was added, and the mixture was extracted with Et2O (4×125 ml). The combined organic phases were dried with MgSO4 and concentrated in vacuo. The crude material was purified by flash chromatography (CH2Cl2/hexanes, 7:3) to provide the title compound as a yellow solid (3.61 g, 64%).

1. temperatureUpon cooling
2. extractionthe mixture was extracted with Et2O (4×125 ml)
3. dry with materialThe combined organic phases were dried with MgSO4
4. concentrationconcentrated in vacuo
5. customThe crude material was purified by flash chromatography (CH2Cl2/hexanes, 7:3)