Acetamide → HCID 59643453, compound

Participants

Reaction Steps

To a mixture of 2-cyclopropyl-2-oxoethyl 4-bromobenzoate (4.51 g, 15.93 mmol) and acetamide (4.71 g, 79.74 mmol) was added BF3/Et2O (1 ml). The mixture was heated at 140C for 8 h. Upon cooling, the mixture was partitioned between water and Et2O. The aqueous phase was extracted with Et2O (1×125 ml). The combined organic phases were washed with Water and brine, dried with MgSO4, and concentrated in vacuo. The crude material was purified by flash chromatography (CH2Cl2/hexanes, 30:70 to 50:50) to yield the title compound as a white crystalline solid (0.69 g, 16%).

Provenance & Evidence