Hydroxyamine hydrochloride → HCID 87693991, compound

Participants

Reaction Steps

To a solution of ethyl 2-[4-(2-{cyano[4-(2-cyclopropyl-1,3-oxazol-4-yl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate (0.38 g, 0.80 mmol) in DMF (2 ml) was added hydroxylamine hydrochloride (0.20 g, 2.94 mmol) followed by sodium acetate (2.88 g, 3.59 mmol). The mixture was stirred at rt for 12 h. The reaction mixture was partitioned between EtOAc and water. The aqueous phase was extracted with EtOAc (2×20 ml). The combined organic phases were washed with brine, dried with MgSO4, and concentrated in vacuo to yield ethyl 2-[4-(2-{[(E)-amino(hydroxyimino)methyl][4-(2-cyclopropyl-1,3-oxazol-4-yl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate (0.46 g) which was used directly without purification.

Provenance & Evidence