2-Bromo-1-(3,4-difluorophenyl)ethan-1-one → 2-[4-(2-{[4-(3,4-Difluorophenyl)-1,3-thiazol-2-yl][4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoic acid

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-1-(3,4-difluorophenyl)ethan-1-one	HCID 2737032	—
Reactant	Ethyl 2-[4-(2-{(aminocarbonothioyl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate	HCID 59643246	—
Product	2-[4-(2-{[4-(3,4-Difluorophenyl)-1,3-thiazol-2-yl][4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoic acid	HCID 10312109	—

Reaction Steps

Similarly prepared from ethyl 2-[4-(2-{(aminocarbonothioyl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate and 3,4-difluorophenacyl bromide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07319104B2
Source dataset	uspto-grants-2008_01
ORD ID	ord-9e78c80345264e9ea0a31be760ae5d0a
Source note	uspto-grants-2008_01