HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 5-Chloro-2-hydroxy-3-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 3-Methoxysalicylic acid | HCID 70140 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Chloro-2-hydroxy-3-methoxybenzoic acid | HCID 676501 | — |
Reaction Steps
step a) 2-hydroxy-3-methoxy-benzoic acid (13) is chlorinated for example with N-chlorosuccinimide in acetic acid to yield 5-chloro-2-hydroxy-3-methoxy benzoic acid (14); step b) the methoxy group of compound (14) is reacted with hydrobromic acid in acetic acid to yield 5-chloro-2,3-dihydroxybenzoic acid (15);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319101B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-4587e8ed799b4dcfaf0764edb72fe1d0 |
| Source note | uspto-grants-2008_01 |