HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-Chloro-2,3-dihydroxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 5-Chloro-2-hydroxy-3-methoxybenzoic acid | HCID 676501 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Chloro-2,3-dihydroxybenzoic acid | HCID 12394882 | — |
Reaction Steps
step a) 2-hydroxy-3-methoxy-benzoic acid (13) is chlorinated for example with N-chlorosuccinimide in acetic acid to yield 5-chloro-2-hydroxy-3-methoxy benzoic acid (14); step b) the methoxy group of compound (14) is reacted with hydrobromic acid in acetic acid to yield 5-chloro-2,3-dihydroxybenzoic acid (15);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319101B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-9a29f7d755374984b439cf51bfb41774 |
| Source note | uspto-grants-2008_01 |