反应详情

6-Bromo-2,2-diphenyl-1,3-benzodioxole-4-carboxylic acid (200 mg, 0.503 mmol, 1 eq.), LiOMe (40 mg, 1 mmol, 2 eq.) and ethyl trifluoroacetate (0.6 mL, 5.03 mmol, 10 eq.) as the electrophile were reacted according to GP4, Method A. The crude product was purified using flash chromatography (silica gel, hexane/EtOAc/AcOH 77:20:3) to give the title compound as a yellowish solid.

1. customThe crude product was purified