反应详情

温度

50 °C

To a solution of 6-(hydroxy-pyridin-4-yl-methyl)-2,2-diphenyl-1,3-benzodioxole-4-carboxylic acid (128 mg, 0.324 mmol, 1 eq.) in a mixture of 10 mL acetone and 3 mL DMSO, IBX (273 mg, 0.973 mmol, 3 eq.) was added and the reaction mixture was stirred 3 h at 50° C. The mixture was partitioned between H2O and EtOAc, and the organic layer was washed with saturated NaCl solution before being dried over MgSO4 and evaporated under reduced pressure to yield the title compound as a yellowish solid.

1. additionwas added
2. customThe mixture was partitioned between H2O and EtOAc
3. washthe organic layer was washed with saturated NaCl solution
4. dry with materialbefore being dried over MgSO4
5. customevaporated under reduced pressure