反应详情

温度

60 °C

To a solution of 4-trifluoromethyl-benzene-1,2-diol (870 mg, 4.8 mmol) in 20 mL CCl4, Br2 (770 mg, 4.8 mmol, 1 eq.) was added and the mixture was stirred at 60° C. for 10 h. The sol-vent was then removed in vacuo and the crude product was purified by flash chromatography (silica gel, hexane/EtOAc 4:1→3:2) to yield the desired product as a yellowish oil.

1. customThe sol-vent was then removed in vacuo
2. customthe crude product was purified by flash chromatography (silica gel, hexane/EtOAc 4:1→3:2)