Acetic Acid → HCID 23329129, compound

Participants

Reaction Steps

27 g of 4-(4-chloro-3-sulfamoylphenyl)-4-oxobutanoic acid are dissolved in 200 ml of methanol, 1 g of acetyl chloride is added and the mixture is stirred at room temperature. After 24 hours, only small amounts of starting material can still be detected in the thin layer chromatogram. The solvent is driven off, the residue is treated with 200 ml of acetic acid/200 ml of water and, after the pH has been adjusted to 8 with saturated sodium bicarbonate solution, the mixture is stirred vigorously for 30 minutes. After separating off the organic phase and drying it over sodium sulfate, the solvent is distilled off and methyl 4-(4-chloro-3-sulfamoylphenyl)-4-oxobutanoate is obtained.

Provenance & Evidence