4,4'-Dimethoxybenzophenone → Methyl 2,2-Bis-(4-methoxy-phenyl)-6-trifluoromethyl-1,3-benzodioxole-4-carboxylate

Participants

Reaction Steps

4,4′-Dimethoxybenzophenone (213 mg, 0.88 mmol, 1.5 eq.), oxalyl chloride (900 mg, 7.1 mmol, 8 eq.) and methyl 2,3-dihydroxy-5-trifluoromethyl-benzoate (130 mg, 0.59 mmol, 1 eq.) were reacted according to GP2.2. The crude product was purified using flash chromato-graphy (silica gel, hexane/Et2O 10:1) to yield the title compound as a yellowish, very viscous oil.

Provenance & Evidence